A vampire is not going to notice a difference between being atomised by a repulsor blast vs being atomised by eye beams or magic. They will just die. Many superpowered people look like normal humans when not in costume. The MCU wants to intoduce as many thing from the comics as possible. Vampire attacks random guy and said guy pops up metalic claws or transforms into a not very jolly green giant. Vampire dies.
All that may be so but on a planet closing in on 8bn people it doesn't matter so much if there are a few hundred super powered beings scattered amongst them. Even in a scenario where vampires do absolutely nothing to assess their prey before sinking their fangs in, the sheer statistical significance is negligible. Let alone the fact that any vampire would presumably look at Thor or Wolverine (incl. comics version) and think: "nah, I'll chomp on that old lady who lives alone in that apartment.". Even without superpowers they're going to think that eating Tony Stark or Captain America is going to attract way more attention than they need. Sure you can give me examples of people on the downlow like Peter Parker but again, we return to the sheer odds which are now even further reduced.
There's no incompatibility between a world with vampires and a world with superhumans. One might argue that there is if the superhumans have some game-changing way of eliminating the vampires, but a vampire is not going to notice a difference between being atomised by a repulsor blast vs. a flamethrower. At best, you can throw in some Deus Ex Machina stuff Strange might pull casting "Nomorus Vampirae" if you want but that's just pulling stuff from the writer's arse they can do with anything.
Nah, vampires in the MCU is fine.
But I got more! We suppose that vampires have been around a while. In The Eternals - my favourite movie of the MCU - the deviants have been evolving and the big deal with their leader is that he has developed the ability to drain others of their energy and powers. There are various vampire style hints about it and at the end he is dispersed in a way that sets up the idea of the power being spread. I believe the original intent was to set up vampires in the MCU. In which case they're not something that has been hiding in the background for a long time but a new phenomenon. IMO, that would be a nice change.
Dr. Strange, Spiderman, many X-men, Ghost Rider, Jessica Jones, Luke Cage, Iron Fist etc etc look like normal humans most of the time. Vampires should start to assume that there are good chances that they will run into one such fellow and get fucked.
No, there are not good chances. See above. There are less than 1:1000,000,000 chances.
Not to mention that big events that leave cities devastated should affect vampires. Their infrastructure is destroyed leaving many homeless and incapable of hiding as easily as they used to, a few of their key members were burned by alien rayguns and evidence of the existense of vampires should be discovered amongst the destroyed buildings. You cannot introduce a thing like vampires this late so easily.
IMO, the chaos of major disasters is a bonanza for feeding and re-establishing cover stories, identities, etc. You have programs for people who lost their papers and identities. Someone to testify who you are? No - both your parents died in the building's collapse and your aunt has been re-located to the Red Cross centre upstate. Someone went missing 'cause you ate them? Lost in the noise of a thousand other displaced and missing people. Hell, toss some rubble on top of the bodies you leave behind and by the time they're dug out nobody will know the cause of death was bloodloss.
But again, see comment about The Eternals and the possibilty of adding vampires in late stage. They wont do it, but I think they were thinking about it.
There's no real reason they can't do Blade. It's just that some motherfuckers are always trying to ice skate uphill.
