Not really. Most of the changes everyone praises are either post game content that's only good as a time waster (Battle Frontier, contests, poffin making, secret bases) or fairly unimportant if you don't care for competitive battling (Natures, EV's/IV's). The only genuine quality of life changes for the average player would be abilities (Gen 3) and the physical special split (Gen 4).
So the only reason to pick them up anymore is competitive battling, but even then, I feel the competitive scene became garbage in Gen 7 due to a lot of changes I find pretty stupid.