I'm kinda wondering if Konami ever actually does try to make a Metal Gear Solid 6, if it would either be a Big Boss game that would actually bridge the gap and show what he was up to before the events of the MSX games separate from Venom, or if they would try to tap into a Solid Snake story again and have an adventure set between 2 and 4 where he goes on another mission for Philanthropy with Otacon at a point before he has the body of a geriatric from the advanced aging. I could very easily see Konami wanting to cynically tap the Solid Snake & Otacon mine of gold again for The Nostalgia™ in a new non-remake, but they also can't really pull out Old Snake for another bout, so I'd imagine something like this would be the middleground. How they would justify its' existence beyond wanting money, I have no idea.