I don't know how Blumhouse can keep milking the Halloween franchise (as they stated after the 2018 release) if they can't keep relying on Jamie Lee Curtis. Unless they go a new route and make separate films that immediately follows the original (like the Millennium series in the Godzilla franchise). They would basically make a hybrid of anthology films, like how John Carpenter wanted the series to be, but keep Michael Myers as the central antagonist. For example, one film could take place several years after the original with a new group of characters (none related to Laurie) being stalked by a returning Michael with Dr. Loomis back on his trail. Since the flashbacks in Halloween Kills include a cast member that was made to look like Donald Pleasance and with him sounding like the late actor, this seemed to be a way featuring the character without using CGI.
My speculating aside, it is depressing to see what has happened with most of the slasher titans.
Michael Myers: Most likely has gone out with a whimper because of modern horror writing.
Freddy Krueger: The 2010 remake pretty much killed any revitalization of the franchise. Also I don't think any amount of makeup can hide Robert Englund's age while Heather Langenkamp seemingly has no thoughts about portraying Nancy Thompson again.
Jason Voorhees: It seems like the longer the legal disputes go, the further into obscurity the character goes.
Leatherface: Netflix tried to follow the coattails of Halloween '18 but ended up butchering the character more much like the last two Texas Chainsaw Massacre films did.
Pinhead: After years of direct-to-video installments, Hulu seemed to breathe new life into the Hellraiser franchise. But some have pointed out how tame this newest entry was given the source material.
Candyman: Instead of being subtle with its racial undertones, the 2021 sequel decided to beat audiences over the head because of current events. Like Robert Englund and Doug Bradley, Tony Todd is getting older and anyone who tries to fill the role will always be compared to him.
I excluded Chucky since the original film series is still going with the TV show just starting its second season. Also the latest Scream did well with the box office, critics, and audiences that another one was greenlit so Ghostface will still be around.