I'm worried about how Disney is going to handle The Simpsons.
As sad as Russi Taylor's passing is, I'm not quite as upset by Grey DeLisle replacing her for Martin Prince and Sherri and Terri. It'd be kind of awkward to retire the kid characters like they did with Krappabel and Hartman's characters, and it's not like Martin Prince or the twins are major characters, especially in the newer seasons.
It's actually not the first time they replaced the voice of an actor who died instead of retiring the character altogether like they did with Mrs. Krappabel or Lionel Hutz and Troy McClure.
Doris Grau was the original voice of Lunchlady Doris and she also had a few bit roles here and there in the early seasons but died around the time of Season 7.
Lunchlady Doris was a relatively minor character and was semi-retired for a few seasons, appearing as an extra but not having lines, but was eventually brought back and voiced by Tress MacNeille.
What I'm really worried about is how they're going to handle the deaths of the core cast members (Dan Castellaneta, Julie Kavner, Harry Shearer, Hank Azaria, Nancy Cartwright, Yeardley Smith, and Tress MacNeille) since Julie Kavner is elderly and rumored to be in poor health, while Harry Shearer and and Dan Castellaneta are also close to the same age group as Kavner.
Replacing Kavner is bad enough since she's the voice of Marge, but what if Dan Castellaneta or Harry Shearer died before they ended the show? Castellaneta is the voice of Homer Simpson, ostensibly the main character of the show and also voices a lot of other major characters as well, such as Grandpa Simpson and Groundskeeper Willie.
The majority of the most famous characters outside The Simpson family are voiced by Harry Shearer and Hank Azaria, so there would be a lot of roles to fill.
I know Disney won't do it, but they really should end the series after Season 32. Maybe they can do a second movie afterwards, but that really should be it.