so LG can be caused by about 50 different genes. Possibly even more but those are the ones we know of.
The goal of rna therapy is to cure very close to genetic source. So say you’ve got a mutation, that mutation is on a gene. The gene ‘works’ by reading off a little transcript of rna, which gets fed, like a punchcard tape, into a protein machine that makes the protein. RNA therapy aims to hit that bit of punchcard tape. Let’s say there’s a spelling error in the middle and it creates a duff protein - well you can design an rna that binds to it and send it to be chewed up. Now the ok copy of the gene is the only one sending transcripts to turn into protein.
There are only a couple of mutations so far that have had specific therapies made. I think scn2a is one. If you dont know the underlying mutation then it’s not an option.
There are other trial option. two trials open in Sf (I have no idea where you are, dont dox yourself ) for example,
https://clinicaltrials.ucsf.edu/lennox-gastaut-syndrome
They also have other locations. One looks like some of brain stimulation stuff and the other is drugs.
If you search on this site you’ll see everything - important to note that a lot of trials don’t aim at all to be curative. They may just be looking at disease progression or equivalent treatments. It’s worth asking your doctors if there is anything open you feel your son might benefit from. And there may not be. It’s not something I think we will have a cure for soon (I think the rna stuff is promising, but the wheels grind slowly…)
You are already doing the most important thing which is being there with him and loving him. At the end of the day, that is what matters.