Meh, I read a few reviews about it. Big boobed Gremlin wants to annoy you is nothing outragous but also nothing special.
But in light of the twitter outcry I thought a bit more about the midget with the flesh tooth:
In my opinion outrage was bound to happen
Give her small breasts- people complain about pedo vibes because she looks like a child.
Give her normal breasts- people complain about pedo vibes because she looks like a child.
Give her huge breasts - people complain about pedo vibes because she looks like a child but also get lots of money from thirsty otaku.
But perhaps giving her large breasts also had another reason: to prevent pedophilia accusations (which didn't work) and/or to prevent the manga from becoming known as loli crap. Big breasts are for the most part a sign of maturity even in japan and especially in anime/manga (not talking about loli fetish bullshit).
So what can you do if you want to include a main character who is small like child (which also emphazises her childish personality) without making kiddie diddler shit? Give her the breasts of a mature woman. There, problem solved and on top of that otaku are going to jerk off to her in their basement and are more likely to buy your manga, animu dvds & merchandise.
The cultural aspect
The annoying but tame adventures of big tit goblin are just a drop in the ocean of manga/anime with a similar premise - bubbly girl teases the shit out of the boring & shy male main character who just wants her to go away.
But you can also look at it from a very different perspective and then you understand that there may be a deeper cultural meaning:
Japan is a country where gender roles are stricter than in the west and also has certain rules for how you should act in society. For example people are going to laugh at you if are holding hands with your significant other in public and kiss him/her. There still is a pressure to conform.
So let's change our perspective:
(Japanese) woman who doesn't give a shit about how society is viewing her is actively pursuing a man. She knows what she wants and she doesn't let anyone get in her way. She doesn't want to hide her personality even if it leads to emberrassing incidents. She is neither shy nor passive.
I guess this is the main reason why social awkward otaku like Uzaki and female otaku might feel empowered (yeah yeah she has huuuge knockers but if that was the main reason less people would watch it because porn is available 24/7). This might be something western weebs don't think about because they are living in a different culture.
Of course there is often fan service because sweet



but it makes sense why nip otaku (& weebs) like Uzaki and similar anime. Because lots of (japanese) men actually like women like this and I bet it's not just guys who watch anime all day long.
Tl;dr the white haired gnome with Robert Paulson tits represents something that's alien to japanese culture as a whole but something that people crave for.