Episode 5 came out and we learn that the totally-not-Mr-House guy we've seen in the bar and the Veterans Hall bathroom is actually Robert House, please pretend to be shocked. He talks with Cooper and directly says Vault-Tec and the other companies at the meeting from season 1 will not end the world. House implies Cooper's wife, the shadowy group behind the deathclaw *cough* The Enclave *cough*, and possibly even Howard himself will actually cause the end of the world. House talks about how he uses his tech to predict the future through math and shit, because his motto is that the House always wins, but he's starting to think he isn't actually the House in this situation.
Freeside is also still around, bit more crowded and ran down, but still together. Lucy goes to steal some addictol from a store and ends up shooting the fake store owner dead after finding the real store owner's cut up body. She goes to the ghoul's room at the Atomic Wrangler where she's informed that the ghoul has agreed to take her back to Vault 33 under threat by Hank, who threatens to kill both Cooper's wife and daughter, who are in the Vault under Vegas. Lucy gets shot with a tranq dart by the ghoul, but due to the addictol it takes a while to work on her, so she punches the ghoul out a window with the Power Fist she also stole, He gets impaled on a pole through the abdomen. Hank then Kidnaps Lucy after she finally passes out.
Also it's confirmed that Future Enterprises Ventures is, in fact, code for the Forced Evolutionary Virus.
I think the show played it's hand way too early in showing that The Enclave was still around in season 1, as it's clear they are setting up the Enclave as the big bad for the latter half of Season 2.