I suppose it's the people who lived in those places that sometimes find it hard to accept their fate when it's namedropped on a big show like The Simpsons. I always think back to the episode where Bart visited a box factory and the class were told that the finished boxes were done up in Flint, Michigan. I wonder how many Flint natives found that a little too on the nose to their then/current situation (Flint once being an auto industry giant in its day).
I believe National Lampoon's Vacation had a joke about that too.
https://youtube.com/watch?v=Ip11Dk8tCBI