I think you'd have to pump and dump pretty quickly. There are already sub-$10 used copies of Dr. Seuss's "Mulberry Street" for sale online - the time window where it sold for hundreds (if indeed any
sold at that price) is already over.
I'm not sure I'm convinced that any modern, mass-produced book that gets canceled (or just goes out of print on its own) will ever be worth that much. Have a look at this "most expensive" list on Abebooks for a few months in 2019:
https://www.abebooks.com/collectibles/most-expensive-sales/april-may-june-2019/
Most of the books on there are either centuries old, highly limited editions, or signed by the most famous authors of all time. "Casino Royale" and "Dracula" are the only plain old books on this list.
Dracula hasn't been cancelled yet, of course, but it shows that the
maximum demand for Dracula is about $7500 for a rare early edition in excellent condition. And you're not going to sell too many at that price.
Out-of-print cult classics are another angle to look at, but they tend to have very low supply and not that high of a price, comparatively.
Example: John D. Clark's "Ignition!", which I recommend now that it's been reprinted. The original went for $500+, and still does... but there are only one or two copies for sale at any given time.
https://www.abebooks.com/servlet/BookDetailsPL?bi=30767958063
If you look at limited editions of popular books, Stephen King released limited editions of all his "Dark Tower" series from some tiny press in New Hampshire, a few thousand copies each, some signed.
https://www.abebooks.com/servlet/Se...ntlyadded=all&sgnd=on&sortby=17&tn=dark+tower
These only go for a couple hundred - more if they're signed by King himself. There will be a few dozen of these on sale at any given time.
I'm just not seeing a scenario where you could make more than a couple thousand off of low-end book speculation. You'd be better off buying a first edition of Isaac Newton and then convincing Netflix to do a Newton docu-drama or something like that.