It'd probably come across better if, in the entire of Star Trek's body of work writers could produce a Prime Directive script that wasn't horrendously contrived, chock full of absolute nonsense, and at its best wasn't a half-cocked ass pull to try to justify it under "well, it wasn't the least ethical thing we could do" crap. Closest we ever got was the Enterprise episode where Phlox discovers an alien species is genetically-nonviable, and while the genetic flaws could be corrected it would be at the expense of another species. Even then the logical hoops the plot has to follow to get from premise to conclusion strain suspension of disbelief to the breaking point -- and the episode even contradicts its own premise at one point, when Phlox observes the two species have developed a culturally symbiotic relationship.
The entire reason the Prime Directive exists as a story element, is to signal how moral and upstanding the main characters are by violating it to save people.