I think her earlier issues were okay, but I wouldn't say you're missing anything by not having read them. I think part of the appeal was they were fun little comics that largely existed in their own bubble. It felt like Marvel was trying to do something in the same ballpark as what DC was doing with Harley Quinn, set up a more lighthearted comic that did have occasional interactions with other characters in the universe, but mostly existed in a self-contained continuity. It didn't really last long, and I think Kamala has suffered for it ever since. The Secret Wars stuff was tonal whiplash, Champions wrote her as incredibly unlikeable and weirdly bitchy towards her teammates, and then for whatever reason the writers decided to take her out of her main series for over a month or so to focus on side characters. Even for an established comic, that can be a risky move, but it isn't something you should do when you haven't even hit issue #100.
Whenever she shows up anywhere else, she feels more like a prop than a character. Her latest appearance in Wolverine was set in the future where she's president of the United States, despite having shown no interest for politics and a pretty open aversion to taking on a leadership role. But, you know, she's one of their brown characters, and Marvel isn't one to pass up the opportunity to virtue signal. I guess she's lucky the artist didn't get the okay to use Riri Williams instead.
