So, to understand this, you have to know that the Catalyst Prime series of books has a meta-origin story. Basically, all metahumans ("enhanced humans" in-story) are the result of some meteor storm or something bullshit. Very comic-book, it's dumb but whatever gets the story rolling.
Anyway, people who are detected as having this metapower, even if they don't know themselves and have no idea that they have powers, get carted off to be poked at by scientists. This is to prevent events like, as told in-story, one metahuman who spontaneously developed powers in the middle of a school who incinerated everyone in the library. It's a prevention thing. I can dig it.
Our main characters are a young black girl named Kathy and a childhood friend named Jonah. Kathy's parents a couple of the scientists in charge of the poking, and they had moved away and recently moved back to town. Jonah is a comic book nerd. He gets bullied a little by some jock and she saves his ass on the bus. So, y'know, they're just alright friends. But a redhead girl sets off an alarm as they get off the bus-turns out she's a meta, so away she goes! Everyone is horrified and concerned, since meta-ness is apparently gained spontaniously, and no one wants to end up like her.
In scientist land there's some hubub about a guy who used some super-strength in some video that went viral. The guy is named after the same comicbook hero that Jonah was reading earlier, so it's all but spelled out that he's the guy (named Cosmosis). The scientists are worried that this means that some metas are "slipping through the cracks" of their search for metas, but before they can try to hunt Cosmosis down Cosmosis tries to break into their lab (presumably to rescue redhead, but it's not stated.)
Issue ends with Cosmosis turning a corner and having a teamed of armed men pointing guns at him.
As far as a #1 goes, it's a pretty alright introduction, but not knowing the meta-origin story would impede your understanding of what's happening. A pretty solid start though, IMO.