UN Monkeypox Article Megathread

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Four more people have been diagnosed with monkeypox in the UK, bringing the total number of cases in the latest outbreak to seven.

All four new patients are gay or bisexual men who were infected in London and had no travel links to Africa, health chiefs have confirmed after MailOnline broke the news earlier today.

Two are known to each other but have no connection to any of the previous cases, in a sign the virus is spreading in the community for the first time.

Nurses and doctors are being advised to stay 'alert' to patients who present with a new rash.

Monkeypox is often mistaken for more common rash illnesses like chickenpox, measles, scabies and syphilis, which makes it difficult to diagnose early.

Dr Susan Hopkins, chief medical adviser at the UK Health Security Agency (UKHSA), said: 'This is rare and unusual.

'UKHSA is rapidly investigating the source of these infections because the evidence suggests that there may be transmission of the monkeypox virus in the community, spread by close contact.

'We are particularly urging men who are gay and bisexual to be aware of any unusual rashes or lesions and to contact a sexual health service without delay.'

All seven UK cases have tested positive for the West African strain of the virus, which is believed to be milder than other versions.
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Six of the seven cases were diagnosed in London while one is being treated at a specialist unit in Newcastle
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Monkeypox is a rare viral infection which causes unusual rashes or lesions (shown in a handout provided by the Centers for Disease Control and Prevention (CDC) in the US

Exactly how the new patients acquired the infection 'remains under urgent investigation', the UKHSA said.

The rare viral infection which kills up to one in ten of those infected but does not spread easily between people. It is transmitted via respiratory droplets during prolonged face-to-face contact or bodily fluids.

MailOnline has learned that at least one sexual health clinic in West London had started implementing tougher infection control measures this morning, including a one-metre social distancing rule in waiting rooms.

A source told MailOnline that some health teams were breaking ranks from national guidance and 'perhaps putting in measures locally'.

The UKHSA announced on May 7 that a person who had recently travelled to Nigeria had contracted the infection.

It was believed they contracted the illness in Nigeria, where monkeypox is endemic, before travelling to the UK.

Two more cases were announced on Saturday, in two individuals who lived in the same household but were not linked to the initial case.
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Nurses and doctors are being advised to stay 'alert' to patients who present with a new rash or scabby lesions (like above)
The rare tropical disease, which causes flu-like symptoms and blisters on the skin, is caused by a virus spread by monkeys, rats, squirrels and other small mammals.

A World Health Organization report last year suggested the natural R rate of the virus – the number of people each patient would infect if they lived normally while sick – is two.

But the real rate is likely much lower because 'distinctive symptoms greatly aid in its early detection and containment,' the team said, meaning it's easy to spot cases and isolate them.

Up to 10 per cent of people who become ill with monkeypox will die and most deaths from the virus occur in younger age groups, according to the WHO.

The first case of monkeypox in a human was recorded in 1970 in the Democratic Republic of the Congo and has since been detected in a number of central and wester African countries.

Most cases are reported in the DRC and Nigeria.

In 2003, the disease was detected in the US when an outbreak occurred following the importation of rodents from Africa.

The first cases were detected in the UK in 2018, when three people contracted the virus after a man travelled back from Nigeria including an NHS nurse who had been caring for a patient and blamed her PPE.

The incident meant more than 50 people were warned they had been exposed to the potentially deadly virus however no other cases were recorded from that outbreak.

A further case was detected in London in December 2019 and another two cases were detected in North Wales in 2021. All cases were thought to have been caught by travellers who had been to Nigeria.

A WHO report in 2020 explained that human-to-human transmission of the virus is rare and that the longest chain of cases appears to only have been six people before it ended.

The report said: 'The epidemic risk for humans is considered to be small.'
 
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Smallpox vaccine is in production and demonstrably works since it eradicated the disease. If it were spreading again, all the boomers are already immune from when the vaccine was in the standard regimen and kids would just get the old vaccine. There’s not really a need to make a new one.
So it'll just wipe out all the antivaxxors? Seems pretty alright with me, but also lines up with big pharmas agenda.
 
So it'll just wipe out all the antivaxxors? Seems pretty alright with me, but also lines up with big pharmas agenda.
Probably not since the boomer segment of antivax people already have it, as do/will military people if things got bad. A new pox vaccine was approved by the FDA in 2019 (it was already used in Europe for a few years prior) and pox vaccines are pretty effective, so there's much lower threshold you need to hit for vaccines to effectively smother out outbreaks. Depending on how much of a minority nu-antivax people are, they won't even notice.
 
At least we have the smallpox vaccine still around. No mRNA vaccines or shit that forces you to produce toxic viral particles.
I have bad news for you: the original smallpox vaccine is a live virus of cowpox selected for low virulence. It sure forces you to produce a truckload of viral particles. It also sometimes leads to a full-blown infection which can even be transmitted to another person.
 
I have bad news for you: the original smallpox vaccine is a live virus of cowpox selected for low virulence. It sure forces you to produce a truckload of viral particles. It also sometimes leads to a full-blown infection which can even be transmitted to another person.
The most modern version uses non-replicating virus, the version you're talking about isn't used anymore. There is an updated version of the one you're talking about that the US keeps in reserve, but it's not distributed by default because of the risk of side effects.
 
The most modern version uses non-replicating virus, the version you're talking about isn't used anymore. There is an updated version of the one you're talking about that the US keeps in reserve, but it's not distributed by default because of the risk of side effects.
How did they test this non-replicating type when there's no smallpox anymore?
 
It's non-replicating cowpox. Also there's still lab-stored smallpox, just not wild smallpox (that we're aware of).
How are we sure that whatever was done to the virus to make it non-replicating, didn't also destroy its usefulness as a vaccine? Some in vitro assays?
 
It's non-replicating cowpox. Also there's still lab-stored smallpox, just not wild smallpox (that we're aware of).

Nope. Not cowpox. The replication-deficient Jynneos vaccine is a modified vaccinia Ankara strain virus. The Jynneos vaccine is 85% effective, and provides protection for 10 years. The risk of myopericarditis is believed to be below that of the ACAM2000 vaccine (although it is currently unknown and cannot be calculated with existing data). Require 2 subcutaneous doses 28 days apart. Those that are vaccinated do not have reasonable protection until they receive the second shot. This vaccine carries no risk of progressive vaccinia nor eczema vaccinatum. It also carries no risk of ocular vaccinia.

The older ACAM2000 vaccine that uses live replication-competent vaccinia virus has a myopericarditis rate of 5.7 per 1,000 first-time vaccine recipients. Requires one percutaneous shot with multiple punctures. Carries the risk of progressive vaccinia and eczema vaccinatum. Two potential serious adverse effects that can occur are postvaccinial encephalitis and ocular vaccinia.
 
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How are we sure that whatever was done to the virus to make it non-replicating, didn't also destroy its usefulness as a vaccine? Some in vitro assays?
Apparently so during its testing phases, as well as animal testing. Even though smallpox is eradicated, the testing for this vaccine happened pre-hysteria, so it's a modification of an existing vaccine that had been developed and tested for 50 years, plus 10 more years of use and testing this current modified version before really getting any use in the USA. Even the most skeptical antivaxers might be more receptive to what's basically a 60 year old vaccine for an illness the vaccines eradicated with a cross-protection for a current illness.
 
There has been talks that an experimental weapon is currently being worked on to combat against those infected. This is classified stuff so view at your own risk
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Nope. It's based on the orthopox virus called vaccinia. The -pox viruses it is most closely related to are Rabbitpox & Buffalopox (Buffalopox is not the same as Cowpox)
Where did you get that? Wikipedia says the american variant is more like horsepox. Perhaps there are different strains in different countries?
 
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