Researchers Report COVID-19 Found in Penile Tissue Could Contribute to Erectile Dysfunction - COVID-19 can be present in the penis tissue long after men recover from the virus.

Original: https://physician-news.umiamihealth...sue-could-contribute-to-erectile-dysfunction/

Archive: https://archive.is/JCxJk

The widespread blood vessel dysfunction, or endothelial dysfunction, that results from the COVID-19 infection could then contribute to erectile dysfunction, or ED, according to the study recently published in the World Journal of Men’s Health. Endothelial dysfunction is a condition in which the lining of the small blood vessels fails to perform all of its functions normally. As a result, the tissues supplied by those vessels could undergo damage.

“Our research shows that COVID-19 can cause widespread endothelial dysfunction in organ systems beyond the lungs and kidneys. The underlying endothelial dysfunction that happens because of COVID-19 can enter the endothelial cells and affect many organs, including the penis,” said study author Ranjith Ramasamy, M.D., associate professor and director of the Miller School’s Reproductive Urology Program. “In our pilot study, we found that men who previously did not complain of erectile dysfunction developed pretty severe erectile dysfunction after the onset of COVID-19 infection.”

Dr. Ramasamy and colleagues collected penile tissue from two men with a history of COVID-19 infection who underwent penile prosthesis surgery for ED. One of the men was hospitalized for COVID-19, while the other patient only had mild symptoms when he contracted the virus.

The researchers also collected tissue from two additional men with no history of COVID-19 infection undergoing the same surgery for ED. The investigators analyzed all the tissue samples for not only evidence of the virus but also endothelial dysfunction.

They found COVID-19 was present in the penile tissue of both men who had been infected, but not in the men with no history of the virus. The men had been infected six and eight months prior, respectively. These men had evidence of endothelial dysfunction, while the men who had been free of the virus did not.

“This suggests that men who develop COVID-19 infection should be aware that erectile dysfunction could be an adverse effect of the virus, and they should go to a physician if they develop ED symptoms,” Dr. Ramasamy said.

The authors hypothesize that similar to other COVID-19 related complications, widespread infection and subsequent endothelial dysfunction could result in ED, and that worsening of ED could be due to the virus’s presence in the penile tissue itself.

In a previously published study, Dr. Ramasamy and Miller School colleagues found that COVID-19 can also invade testis tissue in some men who are infected with the virus, which might be the first step in understanding the virus’s potential impact on male fertility and whether COVID-19 can be sexually transmitted.

“These latest findings are yet another reason that we should all do our best to avoid COVID-19,” said first author Eliyahu Kresch, a medical student working with Dr. Ramasamy.

“We recommend vaccination and to try to stay safe in general,” Kresch said.

Miller School coauthors are medical student Justin K. Achua, M.S.; Russell Saltzman, clinical research coordinator; Kajal Khodamoradi, Ph.D., clinical research associate; Himanshu Arora, Ph.D., research assistant professor of urology; Emad Ibrahim, M.D., HCLD, assistant professor of urology and neurological surgery; Oleksandr N. Kryvenko, M.D., associate professor of pathology; Vani Wolff Almeida of the Transmission Electron Microscopy Core; Fakiha Firdaus; and Joshua M. Hare, M.D., founding director of the Interdisciplinary Stem Cell Institute.

 

[Unassuming Local Guy]

"Obey me or you have smol pp" might as well be the official motto of the American left. I really don't understand their obsession with dicks.

 

[Pickle Dick]

I really don't understand their obsession with dicks.

they all gay

 

[tehpope]

Does it matter? 30% of men today are virgins. I guess guys better wash their hands after jerking it.

 

[Weed Eater]

"Maybe if we tell them it affects their dicks they'll pay attention to us."
Hit 'em where it hurts I guess lol

 

[Drifting Panzer]

The coof just gets better and better. How long until "meat-eaters are more likely to get covid", or is that already a thing and I missed it?

 

[BobbyBriggs69420]

"Obey me or you have smol pp" might as well be the official motto of the American left. I really don't understand their obsession with dicks.

Pretty much, this seems like a last-ditch effort to get ignorant rednecks to put on face panties now that it doesn't even matter. "avram, just make sure the story mentions some kind, any kind of schmeckle dysfunction, that will do the trick on those simple-minded hillbillies"

 

[b0o0pinsn0o0tz]

Why do I have the weirdest feeling the coof never broke any one's dick and this is shitty propaganda?

 

[Exigent Circumcisions]

No guys this is totally real and explains why my dick hasn't got hard in three years.

 

[Drain Todger]

ACE2 receptors, which SARS-CoV-2 latches onto, are largely found in vascular endothelial cells, or ECs.

The vascular endothelium lines the inside of all blood vessels; veins, arteries, and capillaries. It is contiguous with the blood-brain barrier. And, of course, all of the body's organs are, in turn, lined with blood vessels to supply cells with oxygenated blood so they can make energy.

SARS-CoV-2 doesn't just cause edema and vascular injury in the dick, but basically everywhere there are blood vessels, which is everywhere in the body. This was actually confirmed in April of 2020 when scientists in Switzerland determined that COVID-19 is not a viral pneumonia, but an airborne vascular endotheliitis.

COVID-19: also a systemic endotheliitis

COVID-19 was considered to be a lung disease. Up until now, it has been unclear as to why patients are sustaining life-threatening organ failure in organs other than the lungs. An interdisciplinary team from University Hospital Zurich has now shown that SARS-CoV-2 directly elicits inflammation...

www.en.usz.ch

Researchers have concluded that the virus does not attack the host via the lungs, as was previously assumed, but instead it directly attacks the body's defense system via the ACE2 receptors found in endothelial tissue, spreads and causes a general inflammation of the endothelial tissue, which disrupts its protective function. This means that the virus not only triggers the inflammation of the lungs, which then causes further complications, but is also directly responsible for systemic endotheliitis, an inflammation of all endothelial tissue in the body which affects all vessel beds – in heart, brain, lung and renal vessels as well as vessels in the intestinal tract. The consequences are fatal: this results in severe microcirculatory disturbances that damage the heart, trigger pulmonary embolisms and vascular occlusions in the brain and intestinal tract and can also lead to multiple organ failure and even death.

The endothelial tissue of younger patients is usually capable of coping well with the attacks launched by the virus. The situation is different for patients suffering from hypertension, diabetes, heart failure or coronary heart diseases, all of which have one thing in common – their endothelial function is markedly impaired. If patients such as these become infected with SARS-COV-2, they will be particularly at risk, as their already weakened endothelial function will diminish even further, especially during the phase in which the virus reproduces the most.

COVID-19 is, in the end, an endothelial disease

Abstract. The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that

academic.oup.com

The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that normally maintain homeostasis. This tightly regulated palette of functions includes control of haemostasis, fibrinolysis, vasomotion, inflammation, oxidative stress, vascular permeability, and structure. While these functions participate in the moment-to-moment regulation of the circulation and coordinate many host defence mechanisms, they can also contribute to disease when their usually homeostatic and defensive functions over-reach and turn against the host. SARS-CoV-2, the aetiological agent of COVID-19, causes the current pandemic. It produces protean manifestations ranging from head to toe, wreaking seemingly indiscriminate havoc on multiple organ systems including the lungs, heart, brain, kidney, and vasculature. This essay explores the hypothesis that COVID-19, particularly in the later complicated stages, represents an endothelial disease. Cytokines, protein pro-inflammatory mediators, serve as key danger signals that shift endothelial functions from the homeostatic into the defensive mode. The endgame of COVID-19 usually involves a cytokine storm, a phlogistic phenomenon fed by well-understood positive feedback loops that govern cytokine production and overwhelm counter-regulatory mechanisms. The concept of COVID-19 as an endothelial disease provides a unifying pathophysiological picture of this raging infection, and also provides a framework for a rational treatment strategy at a time when we possess an indeed modest evidence base to guide our therapeutic attempts to confront this novel pandemic.

To counteract COVID-19, I recommend two things. One is exercise. If you have endothelial dysfunction, you don't want to keep it that way; it promotes atherosclerosis and all kinds of chronic illness. I also recommend an endothelial support diet rich in Vitamin D, Omega-3, and plant polyphenols. Now, this isn't to treat any disease, but to fortify your body in general against illness. COVID-19 seems to mostly prey on people with pre-existing endothelial dysfunction, as in those who are fat, diabetic, or old, or have crucial vitamin deficiencies. It may be that differences in COVID-19 severity worldwide could be chalked up to differences in diet and general lifestyle.

Diet, supplements may help reverse endothelial dysfunction

A diet low in grains, beans and certain vegetables combined with supplements containing polyphenols improved endothelial reactivity in adults at high CV risk. “Simple removal of ‘healthy’ lectin-containing foods, and taking a few inexpensive supplements, may restore endothelial function to...

www.healio.com

Potential of Food and Natural Products to Promote... : Journal of Cardiovascular Pharmacology

rmation of vasoprotective factors including nitric oxide (NO) and endothelium-dependent hyperpolarization, and an increased level of oxidative stress involving several prooxidant enzymes such as NADPH oxidase and, often also, the appearance of cyclooxygenase-derived vasoconstrictors. Preclinical...

journals.lww.com

 

[Blamo]

Experts find, everybody would have forgotten about Covid-19 if it wasn't basically a forced media meme.

 

[Jeffrey Epstein]

https://youtube.com/watch?v=zviVWnuKGkE
ACE2 receptors, which SARS-CoV-2 latches onto, are largely found in vascular endothelial cells, or ECs.

The vascular endothelium lines the inside of all blood vessels; veins, arteries, and capillaries. It is contiguous with the blood-brain barrier. And, of course, all of the body's organs are, in turn, lined with blood vessels to supply cells with oxygenated blood so they can make energy.

SARS-CoV-2 doesn't just cause edema and vascular injury in the dick, but basically everywhere there are blood vessels, which is everywhere in the body. This was actually confirmed in April of 2020 when scientists in Switzerland determined that COVID-19 is not a viral pneumonia, but an airborne vascular endotheliitis.

COVID-19: also a systemic endotheliitis

COVID-19 was considered to be a lung disease. Up until now, it has been unclear as to why patients are sustaining life-threatening organ failure in organs other than the lungs. An interdisciplinary team from University Hospital Zurich has now shown that SARS-CoV-2 directly elicits inflammation...

www.en.usz.ch

COVID-19 is, in the end, an endothelial disease

Abstract. The vascular endothelium provides the crucial interface between the blood compartment and tissues, and displays a series of remarkable properties that

academic.oup.com

To counteract COVID-19, I recommend two things. One is exercise. If you have endothelial dysfunction, you don't want to keep it that way; it promotes atherosclerosis and all kinds of chronic illness. I also recommend an endothelial support diet rich in Vitamin D, Omega-3, and plant polyphenols. Now, this isn't to treat any disease, but to fortify your body in general against illness. COVID-19 seems to mostly prey on people with pre-existing endothelial dysfunction, as in those who are fat, diabetic, or old, or have crucial vitamin deficiencies. It may be that differences in COVID-19 severity worldwide could be chalked up to differences in diet and general lifestyle.

Diet, supplements may help reverse endothelial dysfunction

A diet low in grains, beans and certain vegetables combined with supplements containing polyphenols improved endothelial reactivity in adults at high CV risk. “Simple removal of ‘healthy’ lectin-containing foods, and taking a few inexpensive supplements, may restore endothelial function to...

www.healio.com

Potential of Food and Natural Products to Promote... : Journal of Cardiovascular Pharmacology

rmation of vasoprotective factors including nitric oxide (NO) and endothelium-dependent hyperpolarization, and an increased level of oxidative stress involving several prooxidant enzymes such as NADPH oxidase and, often also, the appearance of cyclooxygenase-derived vasoconstrictors. Preclinical...

journals.lww.com

Hey man! I make beet juice and I feel like I can run a marathon, so I take your advice good sir, and thus pass on my advice of getting A LOT of Nitric Oxide levels from beets (I mix with pineapple juice for taste and added nutrients). In all honesty, my heartrate feels more effortless and I feel my veins less stressed when I have it and it is more anti-inflammatory than turmeric is, at least in my case.

 

[Big Ruski]

I'm pretty sure the ED is caused by jerking off to too much porn during the pandemic.

 

[Drain Todger]

Hey man! I make beet juice and I feel like I can run a marathon, so I take your advice good sir, and thus pass on my advice of getting A LOT of Nitric Oxide levels from beets (I mix with pineapple juice for taste and added nutrients). In all honesty, my heartrate feels more effortless and I feel my veins less stressed when I have it and it is more anti-inflammatory than turmeric is, at least in my case.

Hell yes. Beet juice is just about one of the best things you can have to ward off COVID-19. Nitric Oxide is actually antiviral against SARS, inhibiting the binding of the Spike. Curcumin, resveratrol, and quercetin are also a good idea. Avoid dietary iron. Mild iron deficiency (but not to the point of anemia) may be protective against COVID-19.

Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19

The ongoing outbreak of COVID-19 has quickly become a daunting challenge to global health. In the absence of targeted therapy and a reported 5.5% case…

www.sciencedirect.com

Dual effect of nitric oxide on SARS-CoV replication: Viral RNA production and palmitoylation of the S protein are affected

Nitric oxide is an important molecule playing a key role in a broad range of biological process such as neurotransmission, vasodilatation and immune responses. While the anti-microbiological properties of nitric oxide-derived reactive nitrogen intermediates ...

www.ncbi.nlm.nih.gov

After going over the primary literature of COVID-19, I determined how it causes severe illness. It's a cascade that goes something like this:

1. SARS-CoV-2 S binds to ACE2, its E protein acts as a calcium ion channel, and its other proteins inhibit cellular Nrf2 and suppress interferon response
2. ACE2 is lost, disinhibiting Angiotensin II and des-arg9-bradykinin
3. Intracellular calcium overload and prostaglandin release occurs
4. Cells producing large quantities of superoxide ROS
5. Superoxide depletes endothelial nitric oxide down to nothing, forming peroxynitrite that creates a vicious cycle of NO depletion by its decoupling of nitric oxide synthase due to oxidation of tetrahydrobiopterin
6. Uncontrolled replication begins with no NO left to suppress it
7. Neutrophils are summoned to the inflammation site and neutrophilia/NETosis sets in
8. ROS starts attacking mitochondrial aconitase and iron regulatory proteins because of their iron-sulfur groups, releasing free iron
9. Hypochlorous acid from neutrophils destroys heme and releases free iron
10. Free iron, hydrogen peroxide, and superoxide react through the Haber-Weiss and Fenton reactions to form hydroxyl radicals
11. Hydroxyl radicals start forming oxidized lipids; oxidized phospholipids, oxidized LDL cholesterol, oxidized cardiolipin
12. Oxidized fats promote autoimmunity (the body sees them as non-self and makes antibodies against them), trigger PRRs, and summon even more leukocytes
13. Vicious cycle of lipid peroxidation destroys cells with ferroptosis

People with high Vitamin D levels have moderated intracellular calcium and reduced ROS release, breaking the chain of damaging events (the initial superoxide never gets released in such large amounts). Same thing with increased nitric oxide and Nrf2 activity (beets, turmeric, etc.), there is more ROS scavenging that dampens the cycle.

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand this serious disease. Thousands of studies are being devoted to understanding its epidemiology, its molecular characteristics, its mechanisms, and the clinical evolution of this viral infection. However, little has been published on its pathogenesis and the host response mechanisms in the progress of the disease. Therefore, we propose a hypothesis based on strong scientific documentation, associating oxidative stress with changes found in patients with COVID-19, such as its participation in the amplification and perpetuation of the cytokine storm, coagulopathy, and cell hypoxia. Finally, we suggest a therapeutic strategy to reduce oxidative stress using antioxidants, NF-κB inhibitors, Nrf2 activators, and iron complexing agents. We believe that this hypothesis can guide new studies and therapeutic strategies on this topic.

Defending oneself from COVID-19 is definitely a diet and exercise and dampening oxidative stress thing.

You know what pisses me off the most about this? These are simple dietary adjustments. They're not the multi-billion-dollar bullshit therapies that the media are pushing on us. This disease is treatable and preventable with adequate sunlight, healthy exercise, and an antioxidant diet, not trapping people indoors and psychologically abusing them and gaslighting them with nonsense.

 

[Mepsi Pax]

Train Dodger, you've done good work on this even if you're a sperg. It's unfuckingbelievable how we've passed the "rational age" of science and are literally losing actual knowledge even as we collect more and more data. It's like the onset of the dark ages, just with computers and gay electronic toys... perhaps it's exactly that: Civilizational collapse for the modern age.

I just want to know when we can start burning witches for stealing people's penises. I've already built a menstrual hut out back for the wife, but I live in constant fear that my penis will be stolen.

 

[Drain Todger]

Train Dodger, you've done good work on this even if you're a sperg. It's unfuckingbelievable how we've passed the "rational age" of science and are literally losing actual knowledge even as we collect more and more data. It's like the onset of the dark ages, just with computers and gay electronic toys... perhaps it's exactly that: Civilizational collapse for the modern age.

I just want to know when we can start burning witches for stealing people's penises. I've already built a menstrual hut out back for the wife, but I live in constant fear that my penis will be stolen.

One of the biggest issues with modernity is information overload and its implications for knowledge discovery. A lot of scientific concepts are getting to be way, way too complicated for one person to handle on their own, hence all these different specialized disciplines they've split off into. I had to pore over 500+ papers and play connect-the-dots between them to figure out the pathology of COVID-19. In the near future, AI “knowledge retrievers” will do what I did. They will be set loose on thousands of papers and find the linguistic connections between concepts. I have a feeling that Biology is one field where this technique actually has a chance of making many new discoveries, simply because of how interconnected biological systems are.

The standard conception of COVID-19 advanced by most media sources has left the public with a false impression of what COVID-19 is and what it does. According to most mainstream news sources, COVID-19 is a viral pneumonia that spreads like the flu and attacks the lower respiratory system, causing acute respiratory distress syndrome, or ARDS, sometimes requiring a ventilator or supplemental oxygen to treat it.

But when you delve into the literature and into science and medical news sites, a completely different picture of the virus emerges. COVID-19 is a vascular endotheliitis that attacks the lining of blood vessels. The reason why the virus causes pneumonia is because it triggers inflammation in the lining of alveolar capillaries, causing fluid to leak into the air spaces. It can, in fact, attack basically any organ from the blood vessels outward, including the brain, heart, lungs, liver, kidneys, GI tract, genitals, and skin. It can trigger sepsis and coagulopathy aggressive enough that ischemic events like strokes and heart attacks can occur. Most of the damage is done by deranged and dysregulated immune cells being tricked by the virus into attacking one's own organs. Many of the inflammatory pathways it triggers are similar to Lupus and Rheumatoid Arthritis. Ventilators are the wrong treatment and can actually cause even more damage by stretching injured blood vessels and promoting even more edema through VILI; ventilator-induced lung injuries.

Ironically, for a bug that was painted as the end of the world, I believe that this virus has a rather simple weakness. It can't set off a hyperinflammatory cascade if your body dampens it to the point where it fails to become a self-reinforcing positive feedback loop. In people with pre-existing endothelial dysfunction from being fat, diabetic, and/or old, this feedback loop happens easily. In healthy people with a good balance of nutrition (that is, no measurable vitamin deficiencies) and healthy, happy blood vessels with ample nitric oxide and minimal oxidative stress, it's very unlikely to kill them.

The number one thing that people should be doing is getting sunlight and going on long walks to strengthen their blood vessels and lose as much weight as possible.

What are the authorities instructing people to do? Stay indoors. Minimize time spend outside. Be sedentary. Be fat. The exact opposite of what we should be doing.

 

[A Gay Retard]

Which needle of autism juice makes my dick work best that's what I need to know

 

[Govt. Shitposting Machine]

Which needle of autism juice makes my dick work best that's what I need to know

Well, Pfizer does make Viagra...
>inb4 viagra shilling becomes prominent after vaccine bux dwindle

 

[Hollywood Hulk Hogan]

Experts find, everybody would have forgotten about Covid-19 if it wasn't basically a forced media meme.

Tell that to the families of 600k dead Americans in the past year.

But anyway, most A&Hers won't care about this because they can't get laid and have attitudes like evangelical boomers anyway

 

[Maurice Caine]

Tell that to the families of 600k dead Americans in the past year.

But anyway, most A&Hers won't care about this because they can't get laid and have attitudes like evangelical boomers anyway

Aww, little pussy's hurt.