I agree with your post, but youre wrong about this last part. Nick was being sarcastic when he made that comment. Even if he might want mainstream success, in more traditional ways, he understands that million dollar extreme will never be a mainstream project. He is also saying that just because they had a questionable podcast appearance it doesn't mean that anything is "over."
The only person this will negatively affect is Sam himself, mostly through online ridicule. I believe the reason why it took him so long to release extreme peace was because he wanted to make sure Nick and Charles pockets were lined from the stand up tour and everything else they've done in between because he was worried this project wouldn't be successful and for all we know it hasn't been. Nick is set up with his streams, and is now scheduling his own personal live tour.
Nick can EASILY do his own thing, he's a very social guy, he's the one that got them the Adult Swim gig, so i can see him doing very well financially in showbiz without Sam. It just feels bittersweet, to be honest. Extreme Peace is this thing we all wanted for so long and, now that it's here, i think it would be better if it had never happened. Sam blew it, they had it back in 2016 and he blew it, you can't recreate the circunstances that made MDE successful (kind of) in the early to mid 2010's.
Sam's no longer interested in doing comedy for comedy's sake, he likes being a pundit, talking about the jews and saving the h'white race (despite having no children of his own).
Charles is kind of the odd one out, i don't know what he could do if they parted ways again. No one was watching his streams or The Palace, the MDE brand was sacrificed to make "Sam Hyde" the brand, so he can't even say that he was part of MDE because no one knows MDE anymore, people know "Sam Hyde".
Anyway, Sam's gonna try to put a clever spin on it, probably gonna say that he wasn't having it with Harland, he didn't want to be on the podcast of some "hollywood faggot", probably even show a document (written after the fact, obviously) to show that destroying Harland's set was premeditated etc.