So after seeing the post about Epstein’s testosterone (which was surprisingly very low), I decided to go through hundreds of documents yesterday and do an analysis of his blood work, which there was a lot of. It turns out he had a lot of persistent health issues that he was paranoid about, low testosterone being one of them. I am not a doctor, I am but a broscientist who is terminally online and had nothing to do yesterday.
JE had his blood drawn over 20 times (that I could confirm in a day, there is likely way more) between 2010 and 2018. He had a rolodex of doctors (Peter Attia being one as everyone has now seen) he would reach out to and saved a lot of full texts relating to his health issues. Despite 10 years of frequent consults and blood tests, he progressively got worse as time went on. Money could not save him.
He had a host of health issues ranging from low testosterone, to pre diabetes, to poor metabolic health (his lipids were awful), to STD’s, parasites, and a just crazy set of problems.
Epstein's mapped out total testosterone levels thanks to Claude
Before I get into the actual data, with all of the talk about biohacking, peptides, Bryan Johnson, etc, there is something this crowd fails to comprehend (which JE was def part of and actually ahead of many people) and that is if the body is a reflection of the soul housed within it and they work in tandem with eachother. They are not separate units (dualism), they form the “whole man”. A poor spirit often manifests itself very clearly in someones face, their eyes.
With this said, despite trying to live free and “young”, his body was perpetually deficient in youth and vitality. His body refused to absorb light as he turned from the light (he was low in Vitamin D). His testosterone and estrogen were low (he had an absence of masculine and feminine energy internally). He hosted parasites and STD’s. His blood was thick with excess, his minerals were out of whack (he had issues with parathyroid to the point of thinking he had an adenoma). He was frequently sick, had random skin issues, the list goes on and on.
JE was in a state of acedia, his soul incapable of receiving grace and his body unable to mend itself despite medication, various therapies, and advice from frankly the wrong doctors. What he needed was a spiritual doctor to mend his soul.
“They that never yet knew they were without God, and in the way to hell, never yet knew the way to heaven. Can a man find he hath lost his God and his soul, and not cry, I am undone? The reason why so few obtain this rest, is, they will not be convinced that they are, in point of title, distant from it and, in point of practice, Contrary to it. Who ever sought for that which he knew not he had lost? “They that be whole need not a physician, but they that are sick” - Richard Baxter, Saints Everlasting Rest (who you all should read)
A Quick Primer: What We're Looking At
Actually because I can't assume prior knowledge, let’s quickly go over the markers that will consistently come up.
Testosterone is measured in nanograms per deciliter (ng/dL). This is what everyone knows as the male hormone. Normal range for adult men is roughly 300-1000, depending on the lab and the man's age. Below 300 is generally considered low. Below 200 is very low. Below 100 is having Jesse Lee Peterson yell BETA at you for the rest of your life.
There are two main ways to test testosterone: immunoassay (IA) and liquid chromatography-mass spectrometry (LC-MS/MS). Immunoassay is cheaper and less accurate (if you are on TRT and you keep getting IA, not good!), particularly at low levels where it can overestimate as it can cross contaminate with other hormones. LC-MS/MS is the gold standard. It is more precise and more reliable. You'll see both in Epstein's records.
Free testosterone is the portion not bound to proteins (SHBG and albumin) and is the biologically active fraction. A man can have low total testosterone but adequate free testosterone if his SHBG is low. This becomes relevant.
Triglycerides are a type of fat in the blood. Normal is under 150 mg/dL. 150-199 is borderline high. 200-499 is high. Above 500 is "severe" and carries risk of acute pancreatitis. Above 1,000 is dangerous.
PTH (parathyroid hormone) comes from the parathyroid glands which are four small structures behind the thyroid that regulate calcium homeostasis through PTH (parathyroid hormone). When blood calcium drops, PTH rises to pull calcium from bones, increase intestinal absorption, and reduce kidney excretion. When calcium is adequate, PTH should be low.
Normal is roughly 15-65 pg/mL. Elevated PTH with high calcium suggests primary hyperparathyroidism, usually a benign tumor on one of the four parathyroid glands. Elevated PTH with low or normal calcium suggests secondary hyperparathyroidism, often caused by vitamin D deficiency.
LH and FSH are pituitary hormones that signal the testes to produce testosterone, they are also markers used to measure fertility. When testosterone is low, LH and FSH should rise, the pituitary tells the testes to work harder. If testosterone is low but LH/FSH are normal or low, the problem is upstream: the hypothalamus or pituitary isn't recognizing the deficiency. This pattern, low testosterone with inappropriately normal gonadotropins, is called secondary hypogonadism and is the hallmark of HPG axis suppression from prior androgen/steroid use.
Homocysteine is an amino acid produced during the metabolism of methionine, another amino acid you get from protein. Normally, homocysteine is recycled back into methionine or converted into cysteine through pathways that require B vitamins (folate (B9) and B12). Elevated homocysteine damages blood vessel walls, promotes atherosclerosis, and is associated with increased risk of heart attack, stroke, blood clots, and cognitive decline. Normal levels are under 10-11 μmol/L; optimal is probably under 8. The most common cause of elevated homocysteine is the MTHFR gene mutation which Epstein had.
Also, citations are there for me to know which file to upload into this. I will not post every single screenshot because it will bloat this and take too long, but I will link to a drive everything for you to see the full pages.
Now his blood work.
2010
The earliest labs in the documents come from March 2010, a Quest panel that gives us our first real snapshot of Epstein's endocrine system [25]. We see,
Total testosterone (LC-MS/MS): 188 ng/dL
Free testosterone: 56.5 pg/mL
FSH: 3.7
LH: 4.1
DHEA-sulfate: 182
IGF-1: 151
Prolactin: 2.6
Progesterone: 1.1
Triglycerides: 279
HbA1c: 6.1%
Homocysteine: 11.5
PTH: 68.9 (elevated)
Calcium: 10
MTHFR: C677T MTHFR mutation x 2
Several things stand out. His testosterone at 188 ng/dL is low for a man of any age. His PTH was already elevated at 68.9, with high calcium, a combination that points toward primary hyperparathyroidism, which would become a recurring concern throughout his records.
His LH and FSH were in normal range despite the low testosterone. This is the first red flag. The fact that his pituitary sat at 3.7 and 4.1 while his testosterone was 188 suggests something was wrong with the feedback loop itself. His hypothalamus had stopped recognizing low testosterone as a problem.
He was also tested for the MTHFR gene mutation and came back positive for two copies of the C677T variant [25]. To his or his doctors credit, this was ahead in my opinion of the mainstream to be even considering testing for this. This is something you hear much more about now.
The MTHFR C677T homozygous mutation impairs the body's ability to convert folate into its active form (methylfolate), which is necessary for methylation. This influences things like:
Neurotransmitter synthesis (serotonin, dopamine, norepinephrine)
DNA repair and gene expression
Detoxification pathways
Homocysteine metabolism
When methylation is impaired, homocysteine can build up. Elevated homocysteine is a cardiovascular risk factor and is associated with cognitive decline, depression, and increased all-cause mortality. As a side note, this is why the form of B vitamins you take matters, cyanocobalamin is not the same as methylcobalamin for b12, or pyridoxine hcl is not the same as pyridoxal 5 phosphate.
Epstein's homocysteine was consistently elevated throughout the records:
March 2010: 11.5 [25]
December 2013: 16.6 [34]
November 2016: 15.2 [2]
August 2017: 15.4 [28]
June 2017: 14.2 [40]
September 2016: 16 [46]
August 2018: 16.1 [44]
November 2018: 12.7 [18]
Normal homocysteine is typically under 10-11 μmol/L. Optimal is probably under 8. His was consistently elevated, sometimes significantly.
The recommended intervention for MTHFR-related hyperhomocysteinemia is methylfolate supplementation and methylcobalamin (active B12, there’s also adenosylcobalamin). One of his doctors recommended sublingual B12 and folic acid in 2011 [29], though ideally the forms would have been methylated versions. Whether Epstein ever optimized this is unclear.
Elevated homocysteine also damages blood vessel walls and promotes atherosclerosis which is consistent with his coronary calcium progression from 53 in 2011 [29] to 84 in 2018 [41].
By November 2010, another Quest panel shows things deteriorating [36]:
Testosterone (LC-MS/MS): 140 ng/dL
Free testosterone: 45.9
Triglycerides: 679 (shot up)
HDL: 26
Vitamin D: 35
PTH: 82 (now flagged for secondary/tertiary hyperparathyroidism)
Estradiol: <2 (essentially undetectable)
DHEA-sulfate: 222
FSH: 4.3
LH: 5.6
AM cortisol: 12.4
His testosterone dropped nearly 50 points in eight months. His triglycerides more than doubled. His PTH climbed from 68.9 to 82.
Normal male estradiol is 10-40 pg/mL. In men, estrogen comes from the aromatization of testosterone, an enzyme converts testosterone to estradiol (man boobs come from excess of this, high fat also aromatizes). He had little to no estrogen.
Again, note the LH and FSH: 5.6 and 4.3. Normal range, when they should be dramatically elevated given his testosterone of 140. The pituitary wasn't responding to the deficiency. This is the pattern of secondary hypogonadism.
The Parathyroid Obsession
Before continuing the timeline, Epstein kept asking over the years about his parathyroid.
Primary hyperparathyroidism occurs when one or more parathyroid glands develops a benign tumor (adenoma) that autonomously secretes PTH regardless of calcium levels. This causes:
Elevated calcium (hypercalcemia)
Elevated PTH (inappropriate given the high calcium)
Symptoms including fatigue, brain fog, depression, muscle weakness, bone loss, kidney stones, and constipation
Secondary hyperparathyroidism occurs when PTH rises appropriately in response to low calcium or low vitamin D. The glands are working correctly and are responding to a deficiency.
Epstein's pattern was complicated. His documented PTH levels over the years:
March 2010: 68.9 with high calcium [25]
November 2010: 82, flagged for secondary/tertiary hyperparathyroidism [36]
July 2011: 104 [29]
September 2013: 43 [47]
January 2018: 83 [10]
November 2017: 87 [31]
September 2017: 106 [38]
Normal is roughly 15-65 pg/mL. His levels were consistently elevated, often well above the upper limit.
In October 2015, a doctor named Dr. Merrill notes he's "waiting on PTH tests again" [19]. In November 2017, Epstein texts a doctor named Dr. Moscowitz asking to "get pth tested" [31]. In July 2018, a CT scan specifically evaluates for parathyroid adenoma and notes his calcium score had risen to 84 from a previous 41 [41]. The scan also revealed fatty liver.
He was right to be concerned. Whether he ever had parathyroid surgery, or whether an adenoma was definitively confirmed, I am not sure. Maybe there is something in there, IDK.
The Maxwell Testimony
In a 2025 deposition, Ghislaine Maxwell made claims about Epstein's testosterone use [33]:
She said he started taking testosterone in the 1990s and that it "altered his character" that "he became more aggressive" and it "made him mean."
In a separate deposition from July 25, 2025, she elaborated [48] that he was on testosterone patches and would wear more than one at a time, which she found "ridiculous." She also claimed he lied about having erectile dysfunction.
This creates an interesting interpretive question that we will come back to at the end, but it brings the possibility of him never recovering from TRT (this is unheard of as far as I know).
2011
In July 2011, Epstein saw a doctor for what appears to be a comprehensive evaluation [29]. The notes revealed that he:
Had a bulging disc (which he constantly dealt with and complained of pain)
Taking statins (Lipitor and Crestor) but complaining of muscle cramps
Triglycerides at 711
Testosterone (LC-MS/MS) at 152
Free testosterone at 38
SHBG of only 11 (very low)
DHEA-sulfate at 217
PTH of 104 (significantly elevated)
Vitamin D at 30 (insufficient)
HbA1c at 5.8%
Coronary calcium score of 53, representing a 13% increase from 2008
The visit notes show he exercised on a treadmill at 20.4 METs with a heart rate of 148 bpm. For reference, 10 METs is considered good fitness for most adults. Elite athletes might hit 20+. Whatever was catastrophically wrong with Epstein metabolically, his heart was fine.
The doctor tries to recommend him a supplement stack of niacin, folic acid, fish oil, magnesium citrate, sublingual B12, and an acidophilus probiotic [29]. He was also advised to meditate and consider a vegan diet lol.
Statin induced myopathy is a well documented phenomenon. Somewhere between 5-20% of patients experience muscle pain, weakness, or cramping on statins, and it's a common reason people discontinue the drugs. Most people are familiar with the coq10 depletion, but this is also prevalent.
Regarding his SHBG, Sex hormone binding globulin is a protein that binds testosterone, making it inactive. Low SHBG means more of whatever testosterone you have is bioavailable, which sounds good, except that chronically low SHBG is associated with insulin resistance, metabolic syndrome, and prior androgen use. It's also one of the markers that can suggest a history of testosterone or steroid use.
Around this same time, September 2011, Epstein emails someone asking about clomiphene [5]. This is the first mention of Clomid in the records that I could find, and comes up all the time.
2013
By late 2013, a LabCorp panel showed the following [47]:
Triglycerides: 993 (wow!)
Testosterone: 178
LDL-P: 2,111 (particle count, very high)
Glucose: 103
Insulin: 26.1 (elevated, suggesting insulin resistance)
DHT: 16
PTH: 43 (lower this time)
DHEA: 207
Prolactin: 4.2
IGF-1: 127
Optimal fasting insulin is generally considered to be under 5-10. At 26, Epstein was profoundly insulin resistant.
Insulin resistance has a direct relationship to triglyceride production. When cells become resistant to insulin, the liver compensates by producing more triglycerides through a process called de novo (new) lipogenesis (creation of fat). The liver essentially converts excess glucose into fat. His insulin resistance was likely directly driving the triglyceride production.
He also randomly had an "equivocal" Lyme test with some antibodies present [47]. Whether he actually had Lyme or this was a false positive, not sure.
A Quest panel from December 2013 shows [34]:
Testosterone: 163
HDL: 28
Homocysteine: 16.6 (high)
Glucose: 114 (pre-diabetic range)
In February 2013, someone emailed Epstein a BBC article asking whether testosterone would make you live longer [13]. This was an early sign he was reading stuff about it. I also forgot to include this, but he was looking into investing into medical companies that dealt with testosterone related issues or made drugs adjacent to it.
2014-2015
By August 2014, Epstein started seeing, or speaking to at least, Dr. Moscowitz. He emails Epstein with the following results [14]:
Cholesterol: 209
HDL: 31
Triglycerides: 462
Testosterone: 142 ("still low")
A text from another doctor in September 2014 reports testosterone at 152.9 [32].
In January 2014, Dr. Moscowitz, texts him: "Also your free testosterone is normal meaning diet and weight loss will reverse testosterone issue" [9].
If free testosterone is adequate, total testosterone matters less. Lifestyle intervention is the obvious of course thing anyone should do, but I am not sure he ever did it.
In May 2015, Moscowitz writes: "Free testosterone normal vit d 41 normal feeling any better?" [12]. The implication is that despite low total T, free T was acceptable and vitamin D had improved. Sorry I lost this one in my files so no screenshot.
Also in May 2015, there's a magazine article on testosterone in the documents [7]. Again, he was very interested in figuring out this problem.
The documents also contain a full-text study titled "National-level Indicators of Androgens are Related to the Global Distribution of Scientific Productivity and Science Nobel Prizes" [35] exploring correlations between population testosterone levels and intellectual output. And a letter to the editor about digit ratio as a biomarker for fetal testosterone exposure and its relationship to adult athletic performance [37]. These give a sense of his intellectual interests and curiosity about testosterone. He was interested in testosterone as a population-level variable affecting achievement and capability, and maybe sought to apply this to him? Not sure.
side bar: as I am typing this, I have reached the max amount of pictures per article.... so they have to be placed as links now sorry
By August 2015, a Quest panel shows testosterone at 129 [21]. By October 2015, Bioreference labs report [30]:
Testosterone: 112.3
Free testosterone: 29.82
Triglycerides: 348
HbA1c: 5.9%
Prolactin: 3.4
His testosterone hit its documented low point in October 2015: 112.3 ng/dL.
Also in October 2015, he saw his old doctor again, who notes [19]:
Triglycerides: 1,053
Vitamin D: 24.8 (deficient)
Waiting on PTH results again
Advised to try Clomid (a drug that can help raise testosterone in men and is often used as a form of whats called post cycle therapy for steroid users getting off. There is also another drug called enclomiphene that is related, but arguably superior for this purpose with less side effects).
This is the first time we see triglycerides break into four figures. And the vitamin D deficiency persists, it appears in nearly every panel, hovering between 24 and 41 throughout the entire documented period. Chronic vitamin D deficiency alone can drive secondary hyperparathyroidism, fatigue, depression, and impaired immune function.
In November 2015, Epstein receives an email with a screenshot from a study about triglyceride changes after five years of TRT [1].
https://imgur.com/a/8lBQGAQ
2016: His lowest T level and insight into Clomid usage
June 2016 brings the most dramatic testosterone reading. Epstein texts Dr. Moscowitz [16]:
"Testosterone 65? All time low"
For reference, women typically have testosterone levels between 15-70 ng/dL. At 65 ng/dL, Jeffrey Epstein had the testosterone of a postmenopausal woman.
In July 2016, Bioreference labs show triglycerides at 950 with a DHT of 148 and HbA1c of 5.9% [42].
In July 25, 2016, Epstein summarizes his health situation to Dr. Moscowitz saying [20]:
https://imgur.com/a/DFXCyxz
"Bruce. lets summarize. angioedema. belly pattern, brain fog. sinus swollen. apnea - lumbar stenosis 1415, greatly reduced urine stream. --low libido bladder ultrasound negative, blood tests - low testosterone, high triglycerides. all cultures neg. semen urine. two cahill parasites positive, whipworm and hisiliyita. medicines to date - medrol. claritin, zantac. magnesium supplement for constipation. can't figure it out. tawari found little, but suggested mri prostate, as no downside. cystoscope. possible stricture from years ago. made it too uncomfortable in office. lets talk"
Thats a lot of ailments, I thought I had a lot! So he has angioedema (swelling), abdominal fat distribution ("belly pattern"), brain fog, sinus issues, sleep apnea, spinal stenosis, urinary problems, low libido, and intestinal parasites, whipworm and what he spelled "hisiliyita," or Entamoeba histolytica, the amoeba that causes amoebic dysentery. He also mentions wanting an MRI of his enlarged prostate [20].
Remember the prostate. We'll come back to it.
In August 2016, Epstein texts Dr. Moscowitz asking if there is "a elevated histamine low testosterone connection" [27]. He was looking for connections his doctors might have missed. Dr. Moscowitz says he has no information on that. The texts between Epstein and Moscowitz reveal the ongoing deliberation about treatment [27]:
https://imgur.com/a/8RTTUR2
Epstein: "did you get the final results for the testosterone?"
The doctor notes: "the only thing we know for sure is high triglycerides and low testosterone... exercise. I assume aspirin, statin?" He also asks: "did we do a prolactin and endocrine panel? This showed many years ago, when you found the high pth"
Moscowitz: "Testosterone replacement is an option"
Epstein: "do you have a view on clomiphene instead?"
Epstein knew enough to ask about clomiphene, a selective estrogen receptor modulator (SERM) that blocks estrogen receptors at the hypothalamus and pituitary, forcing increased LH and FSH output, which then ideally stimulates natural testosterone production.
By September 2016, LabCorp shows [46]:
https://imgur.com/a/pkupdSz
Triglycerides: 470
HDL: 27
Testosterone: 153
DHEA: 155.3
Cortisol: 14.1
IGF-1: 151
Homocysteine: 16
In November 2016, a Quest panel (LC-MS/MS this time) showed [24]:
Testosterone: 194
Free testosterone: 44.6
Triglycerides: 988
Another Quest panel from November 25, 2016 showed [2]:
Testosterone (immunoassay): 185
HDL: 30
Triglycerides: 197 (finally a drastically lower reading)
Homocysteine: 15.2
HbA1c: 5.9%
Uric acid: 8.7 (high)
And Bioreference from December 2016 showed[15]:
https://imgur.com/a/pK274BQ
Testosterone: 146
Triglycerides: 382
The Peter Attia Connection
Peter Attia, famous longevity doctor/expert whatever you want to call him, pops up for the first time I believe here. In February 2016, Attia emails Epstein with results [23]:
“Testosterone went up from 159 to 313
Free T from 4.08 to 7.6
Triglycerides went down from 300 to 203”
This is the only time where we see Epstein's testosterone meaningfully improve. Whatever Attia had him doing worked, at least temporarily. The numbers nearly doubled. And triglycerides came down significantly. As a side note, PA says he was never officially JE's doctor, clarifying that here.
But then in February 2016, Epstein emails Attia about clomid [51]:
"I stopped the clomid the water retention and fat around the waist made it as if i was pregnant. and STUPID"
He called Clomid a "giant mistake" [51].
https://imgur.com/a/QRpJ0kZ
In December 2015, he had emailed another doctor asking if clomid gives headaches [50], but in July 2016, he texts Dr. Moscowitz claiming that Clomid "helped his back" [49]. The relationship with the drug was complicated and inconsistent.
https://imgur.com/a/1I6V9s4
Jeffrey Epstein’s Prostate
In the documents, there's a transcript of a recorded conversation between Epstein and someone named Richard [17]. They're discussing biology, viruses, Viagra (there’s also a picture of viagra prices he was getting, he had the hook up!), and various health topics.
https://imgur.com/a/bTGRded
Epstein: "But we were talking Viagra and he said he's a much bigger fan of testosterone. Jerry Edelman says if you fuck with nature you're going to end up doing something bad to yourself. And if you want to play with that curve, that curve does weird things to you. Nature seems to have a way of getting back to you."
Richard tells Epstein that TRT causes shutdown, and Epstein responds: "It's that FSH/LSH [sic] deal, right?" [17]
Then Richard says: "You can have high testosterone and still have a need for Viagra, because you don't have a prostate, right?"
Epstein says he does not have a prostate [17]. I couldn’t find anything else about this, but I also was sleepy so someone else can search more on this. According to Dr. Bakri, JE did not have a thymus.
Abud Bakri MD
@AbudBakri
·
Feb 1
Epstein had no thymus
Makes sense
But as I showed earlier, in July 2016, Epstein tells Dr. Moscowitz he has an enlarged prostate and wants an MRI of it. He also got his PSA tested a lot, a marker for prostate cancer [20].
So I guess there are a few possibilities:
He had a partial prostatectomy
He lied in one of these conversations (or exaggerated)
He was confused about his own anatomy
The Richard conversation predates July 2016 and something changed medically that surprisingly isnt talked about much.
2017
In June 2017 his Quest panel showed [40]:
https://imgur.com/a/E17KLSP
Triglycerides: 375
Homocysteine: 14.2
HbA1c: 6.2% (creeping toward diabetic range)
Testosterone (immunoassay): 149
Vitamin D: 36
In August 2017 we see his Quest panel show [28]:
https://imgur.com/a/FEXqaYA
HDL: 25
Triglycerides: 532 (back up)
Homocysteine: 15.4
HbA1c: 5.7%
Testosterone (immunoassay): 197
In August 2017 his Bioreference lab showed [43]:
https://imgur.com/a/oYLiGDi
Triglycerides: 1,510 (geez!)
Glucose: 105
Positive for herpes and chlamydia
Finally, his September 2017 blood test showed [38]:
https://imgur.com/a/vUktskD
Triglycerides: 646
Vitamin D: 31
PTH: 106 (elevated again)
Testosterone: 194.3
Free testosterone: 52.04
LH: 3.8
FSH: 4.2
October 2017, Dr. Moscowitz emails: "testosterone 125" [11].
In November 2017, Epstein texts Dr. Moscowitz asking about metformin and whether it's worth using [31]. He wants his PTH tested again. His testosterone is 114, and PTH is 87. He was interested in metformin, a diabetes drug increasingly popular in longevity circles for its potential anti-aging effects. He was aware of the discourse.
https://imgur.com/a/Gvxhz8e
2018: The Final Year of Records
In January 2018, Dr. Moscowitz emails: "Testosterone 150 PTH 83" [10].
https://imgur.com/a/VKsCnXY
In August 2018, Dr. Moscowitz emails: "testosterone level is 150" [26].
https://imgur.com/a/gwynYrB
In Epsteins Quest panel, seperate from whatever Dr. Moscowitz was quoting, from August 3, 2018, it showed the following [44]:
https://imgur.com/a/kAME2pq
HDL: 29
Triglycerides: 855
Homocysteine: 16.1
Glucose: 106
HbA1c: 5.7%
Testosterone (immunoassay): 206
Vitamin D: 32
A 2nd Quest panel from August 30, 2018 showed (the 3rd for the month of August?) [8]:
https://imgur.com/a/cKeAfet
Testosterone (immunoassay): 94
In September 3, 2018, Epstein texts Dr. Moscowitz [3]:
Testosterone: 122
Triglycerides: 495
He comments: "he also thought that endogenous testosterone would make the lipid profile worse"
There's research suggesting that low testosterone correlates with worse lipid profiles, as does low estrogen, which Epstein clearly had.
https://imgur.com/a/yOCLE4D
In September 18, 2018, he had yet again another LabCorp test showing [22]:
https://imgur.com/a/oJaAfl4
Testosterone: 140
Triglycerides: 1,714 (THE HIGHEST SO FAR!)
LH: 3.7
FSH: 4.4
At his triglyceride level, you're at risk of acute pancreatitis. His blood probably wouldn’t have looked to hot either in the tubes!
Later, a CT scan from July 2018 notes fatty liver and concern about a possible parathyroid adenoma [41]. His coronary calcium score had risen to 84 from 41 previously.
The last comprehensive Quest panel in the documents is from November 23, 2018 [18]:
https://imgur.com/a/W3J3v5E
Testosterone (LC-MS/MS): 153
Free testosterone: 42.5
Glucose: 111
Homocysteine: 12.7 (improved)
Triglycerides: 935
HDL: 23
Still hypogonadal with hypertriglyceridemia and low HDL. Eight months before his arrest.
So What Actually Happened?
So how can we explain his health issues (at least what I have covered, again he had tons of skin problems and other things, but maybe for another time)?
He had access to excellent medical care. Peter Attia is one of the most sought-after longevity physicians in the country. Dr. Moscowitz communicated with him regularly. He got tested constantly. He researched papers on testosterone and triglycerides [1], collected studies on androgens and achievement [35, 37], read articles in magazines [7] and from the BBC [13].
There is a lot of irony in this. Here was a man fixated on optimization and on testosterone as a driver of achievement and vitality, but failed to actually do anything meaningful about his own levels. In a Lawrence Krauss email [39] the physicist writes to Epstein: "she also laughed about the testosterone comment.. and wanted you to know she sucked it all out of me last week when she was here."
https://imgur.com/a/wST2pIE
While crude, it confirms testosterone was a running topic in Epstein's social circle, something he talked about openly enough that friends made jokes about it.
Ultimately what the records show is a man who was unwell, knew he was unwell, sought treatment for being unwell, and remained unwell. He had every resource. He had doctors who would test anything he asked. And despite the obsessive monitoring, twenty+ lab panels across nine years, constant texting, CT scans, specialist consultations, experimental therapies, nothing happened.
If Maxwell is correct that Epstein started TRT in the 1990s and used it for years, possibly a decade or more, then there's a plausible explanation for everything we see in these records.
The phenomenon is called post-TRT hypogonadism or, in the context of higher-dose androgens, anabolic steroid-induced hypogonadism (ASIH).
When you take exogenous testosterone, the hypothalamus detects adequate (or supraphysiologic) androgen levels and stops releasing GnRH (gonadotropin-releasing hormone). Without GnRH, the pituitary stops releasing LH (luteinizing hormone) and FSH (follicle-stimulating hormone). Without LH and FSH, the testes stop producing testosterone and begin to atrophy from disuse (small balls is what steroid users will tell you about, but to take HCG to reverse this)
In most men, if not all men, this reverses when TRT stops. The hypothalamic-pituitary-gonadal (HPG) axis recovers over weeks to months. The testes resume production, especially when combined with other drugs like clomid, enclomiphene, HCG, and a couple of others.
I don’t know of anyone who has never recovered from TRT or past steroid use. But in Epstein’s case, maybe he’s a first? He also could have been ODing on pain killers or things that also reduced his testosterone, idk.
This theory also explains several other patterns in the documents:
Why would he keep asking about clomiphene rather than TRT [4, 5]? He may have intuited, or had been told, that more exogenous testosterone would just perpetuate the problem.
Why was his SHBG was so low (11 in 2011) [29]? Chronic androgen use suppresses SHBG. Low SHBG is also associated with insulin resistance and metabolic syndrome. Both fit.
Maybe he was under severe stress with all of the media attention? In August 2013, in an email to an unknown person [45], In what appears to be an emotional message to a romantic partner, Epstein writes: "I didn't want to worry you or involve you, as my testosterone levels can't handle the stress. You don't ask me how I am."
https://imgur.com/a/FUSRa53
But maybe that's the wrong frame entirely. Maybe the question isn't why his protocols failed. Maybe the question is why his body refused to heal in the first place.
I opened this by saying the body is a reflection of the soul housed within it. Epstein’s lab tests were basically a spiritual autopsy conducted while he was alive. Physical ailments are the outward manifestation of inward spiritual corruption. Paul writes about this (Bible Paul not Lindy Paul). If you are concerned with longevity and biohacking, the most important and first thing you can do for yourself is soul care. This can only be done through one way, the way JE knowingly and willfully turned from.
